Endocrine Abstracts

Background: The growth hormone system (growth hormone, GH and insulin-like-growth-factor I, IGF-I) might be implicated in congestive heart failure (CHF). In experimental models IGF-I increases cardiac contractility and reduces apoptosis of myocytes exposed to ischemic injury. In clinical studies GH-therapy has been used in CHF. One previous population based investigation showed that low levels of IGF-I was associated with an increased incidence of CHF. The result of this inves...

Objective: Untreated overt hyperthyroidism is known to predispose the patient to cardiovascular diseases, while predisposition in subclinical hyperthyroidism has been debated. The1 cut-off point of TSH for initiating treatment in subclinical hyperthyroidism is still undefined.Method: A community-based prospective study including non-hospitalised participants, aged 51 to 91 years, living in Copenhagen, Denmark were examined between September 1998 and Janu...

Background and aim: Low T3 syndrome is associated with a poor prognosis in patients with chronic heart failure (CHF). It is controversial whether T3 treatment is indicated in CHF. A previous study using intravenous infusion of T3 for 72 h suggested a beneficial effect on cardiac performance.We aimed to evaluate the effect of 13 weeks of T3 treatment in patients with stable CHF on left ventricular ejection fraction (LVEF) compared to placebo.<p class=...